AustralieFrV1, Main, Exploration, bibRecord, 007064

Role of chemotherapy and molecularly targeted agents in the treatment of adenoid cystic carcinoma of the lacrimal gland

Identifieur interne : 007064 ( Main/Exploration ); précédent : 007063; suivant : 007065

Role of chemotherapy and molecularly targeted agents in the treatment of adenoid cystic carcinoma of the lacrimal gland

Auteurs : Christophe Le Tourneau [France, Niger] ; Albiruni R A. Razak [Canada] ; Christine Levy [France] ; Valentin Calugaru [France] ; Olivier Galatoire [France] ; Rémi Dendale [France] ; Laurence Desjardins [France] ; Hui K. Gan [Australie]

Source :

British Journal of Ophthalmology [ 0007-1161 ] ; 2011-11.

RBID : ISTEX:A98138A4D9375D8FFEF3D33B382D44F5404C7005

Descripteurs français

Wicri :
- topic : Adjuvant.

English descriptors

Abstract

Adenoid cystic carcinoma (ACC) is the most common malignant epithelial cancer of the lacrimal gland. Despite a slow rate of growth, ACCs are ultimately associated with poor clinical outcome. Given the rarity of this disease, most recommendations regarding therapy are guided by expert opinion and retrospective data rather than level 1 evidence. Surgery and postoperative radiation therapy are commonly used as initial local treatment. In patients at high risk of recurrence, concomitant platinum-based chemotherapy may be added to postoperative radiotherapy in an attempt to enhance radio-sensitivity. While encouraging responses have been reported with intra-arterial neoadjuvant chemotherapy, this strategy is associated with substantial toxicity and should be considered investigational. For patients with metastatic disease not amenable to surgery or radiotherapy, chemotherapy may have a role based on its modest efficacy in non-lacrimal ACC. Similarly, molecular targeted agents may have a role, although the agents tested to date in non-lacrimal ACC have been disappointing. A better understanding of the biology of ACC will be crucial to the future success of developing targeted agents for this disease.

Url:

https://api.istex.fr/document/A98138A4D9375D8FFEF3D33B382D44F5404C7005/fulltext/pdf

DOI: 10.1136/bjo.2010.192351

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoid</term>
<term>Adjuvant</term>
<term>Adjuvant chemotherapy</term>
<term>Apoptosis</term>
<term>Apoptosis proteins</term>
<term>Carcinoma</term>
<term>Cell carcinoma</term>
<term>Cell lines</term>
<term>Chemotherapy</term>
<term>Cisplatin</term>
<term>Clin</term>
<term>Clin cancer</term>
<term>Clinical outcome</term>
<term>Egfr</term>
<term>Epidermal</term>
<term>Epidermal growth factor receptor</term>
<term>Epithelial</term>
<term>Extracellular</term>
<term>Gland</term>
<term>Growth factor</term>
<term>Her2</term>
<term>Imatinib</term>
<term>Imatinib mesylate</term>
<term>Immunohistochemical study</term>
<term>Inhibitor</term>
<term>Institut curie</term>
<term>Kinase</term>
<term>Lacrimal</term>
<term>Lacrimal gland</term>
<term>Lacrimal gland adenoid</term>
<term>Matrix</term>
<term>Metastasis</term>
<term>Metastatic</term>
<term>Metastatic disease</term>
<term>Mutation</term>
<term>Neck cancer</term>
<term>Neoadjuvant</term>
<term>Neoadjuvant chemotherapy</term>
<term>Oncogene homologue</term>
<term>Oncol</term>
<term>Ophthalmol</term>
<term>Oral pathol</term>
<term>Partial response</term>
<term>Pathol</term>
<term>Pathway</term>
<term>Perineural</term>
<term>Perineural invasion</term>
<term>Postoperative radiotherapy</term>
<term>Prognostic</term>
<term>Radiotherapy</term>
<term>Receptor</term>
<term>Recurrence</term>
<term>Retrospective data</term>
<term>Salivary</term>
<term>Salivary adenoid</term>
<term>Salivary gland</term>
<term>Salivary gland adenoid</term>
<term>Salivary gland carcinoma</term>
<term>Salivary gland carcinomas</term>
<term>Salivary glands</term>
<term>Solid tumors</term>
<term>Systemic therapy</term>
<term>Tumour</term>
<term>Vegf</term>
<term>Vegf expression</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Adenoid</term>
<term>Adjuvant</term>
<term>Adjuvant chemotherapy</term>
<term>Apoptosis</term>
<term>Apoptosis proteins</term>
<term>Carcinoma</term>
<term>Cell carcinoma</term>
<term>Cell lines</term>
<term>Chemotherapy</term>
<term>Cisplatin</term>
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<term>Clin cancer</term>
<term>Clinical outcome</term>
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<term>Epidermal</term>
<term>Epidermal growth factor receptor</term>
<term>Epithelial</term>
<term>Extracellular</term>
<term>Gland</term>
<term>Growth factor</term>
<term>Her2</term>
<term>Imatinib</term>
<term>Imatinib mesylate</term>
<term>Immunohistochemical study</term>
<term>Inhibitor</term>
<term>Institut curie</term>
<term>Kinase</term>
<term>Lacrimal</term>
<term>Lacrimal gland</term>
<term>Lacrimal gland adenoid</term>
<term>Matrix</term>
<term>Metastasis</term>
<term>Metastatic</term>
<term>Metastatic disease</term>
<term>Mutation</term>
<term>Neck cancer</term>
<term>Neoadjuvant</term>
<term>Neoadjuvant chemotherapy</term>
<term>Oncogene homologue</term>
<term>Oncol</term>
<term>Ophthalmol</term>
<term>Oral pathol</term>
<term>Partial response</term>
<term>Pathol</term>
<term>Pathway</term>
<term>Perineural</term>
<term>Perineural invasion</term>
<term>Postoperative radiotherapy</term>
<term>Prognostic</term>
<term>Radiotherapy</term>
<term>Receptor</term>
<term>Recurrence</term>
<term>Retrospective data</term>
<term>Salivary</term>
<term>Salivary adenoid</term>
<term>Salivary gland</term>
<term>Salivary gland adenoid</term>
<term>Salivary gland carcinoma</term>
<term>Salivary gland carcinomas</term>
<term>Salivary glands</term>
<term>Solid tumors</term>
<term>Systemic therapy</term>
<term>Tumour</term>
<term>Vegf</term>
<term>Vegf expression</term>
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<front><div type="abstract">Adenoid cystic carcinoma (ACC) is the most common malignant epithelial cancer of the lacrimal gland. Despite a slow rate of growth, ACCs are ultimately associated with poor clinical outcome. Given the rarity of this disease, most recommendations regarding therapy are guided by expert opinion and retrospective data rather than level 1 evidence. Surgery and postoperative radiation therapy are commonly used as initial local treatment. In patients at high risk of recurrence, concomitant platinum-based chemotherapy may be added to postoperative radiotherapy in an attempt to enhance radio-sensitivity. While encouraging responses have been reported with intra-arterial neoadjuvant chemotherapy, this strategy is associated with substantial toxicity and should be considered investigational. For patients with metastatic disease not amenable to surgery or radiotherapy, chemotherapy may have a role based on its modest efficacy in non-lacrimal ACC. Similarly, molecular targeted agents may have a role, although the agents tested to date in non-lacrimal ACC have been disappointing. A better understanding of the biology of ACC will be crucial to the future success of developing targeted agents for this disease.</div>
</front>
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<country name="Niger"><noRegion><name sortKey="Le Tourneau, Christophe" sort="Le Tourneau, Christophe" uniqKey="Le Tourneau C" first="Christophe" last="Le Tourneau">Christophe Le Tourneau</name>
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<country name="Canada"><noRegion><name sortKey="Razak, Albiruni R A" sort="Razak, Albiruni R A" uniqKey="Razak A" first="Albiruni R A" last="Razak">Albiruni R A. Razak</name>
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Role of chemotherapy and molecularly targeted agents in the treatment of adenoid cystic carcinoma of the lacrimal gland

Role of chemotherapy and molecularly targeted agents in the treatment of adenoid cystic carcinoma of the lacrimal gland

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri